Predictors of punding in Parkinson's disease: Results from a questionnaire survey
Identifieur interne : 000D16 ( Main/Corpus ); précédent : 000D15; suivant : 000D17Predictors of punding in Parkinson's disease: Results from a questionnaire survey
Auteurs : Andrew J. Lawrence ; Andrew D. Blackwell ; Roger A. Barker ; Francesca Spagnolo ; Luke Clark ; Michael R. F. Aitken ; Barbara J. SahakianSource :
- Movement Disorders [ 0885-3185 ] ; 2007-12-15.
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Abstract
Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self‐report questionnaire was adapted to assess punding in the context of dysfunctional hobby‐related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non‐PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease‐related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT‐related nonmotor behavioral problems in PD. © 2007 Movement Disorder Society
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DOI: 10.1002/mds.21702
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F." last="Aitken">Michael R. F. Aitken</name><affiliation><mods:affiliation>Department of Experimental Psychology, University of Cambridge, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</mods:affiliation></affiliation></author><author><name sortKey="Sahakian, Barbara J" sort="Sahakian, Barbara J" uniqKey="Sahakian B" first="Barbara J." last="Sahakian">Barbara J. Sahakian</name><affiliation><mods:affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Psychiatry, University of Cambridge School of Medicine, Cambridge, United Kingdom</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-12-15">2007-12-15</date><biblScope unit="volume">22</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2339">2339</biblScope><biblScope unit="page" to="2345">2345</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">F512F630D798CBFDF1E35E72879BD0EC392B2AF8</idno><idno type="DOI">10.1002/mds.21702</idno><idno type="ArticleID">MDS21702</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>age of onset.</term><term>compulsion</term><term>dopamine</term><term>impulsivity</term><term>side‐effects</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self‐report questionnaire was adapted to assess punding in the context of dysfunctional hobby‐related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non‐PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease‐related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT‐related nonmotor behavioral problems in PD. © 2007 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Andrew J. Lawrence BA</name><affiliations><json:string>Department of Experimental Psychology, University of Cambridge, United Kingdom</json:string><json:string>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</json:string></affiliations></json:item><json:item><name>Andrew D. Blackwell PhD</name><affiliations><json:string>Department of Psychiatry, University of Cambridge School of Medicine, Cambridge, United Kingdom</json:string></affiliations></json:item><json:item><name>Roger A. 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Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self‐report questionnaire was adapted to assess punding in the context of dysfunctional hobby‐related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non‐PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease‐related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. 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These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT‐related nonmotor behavioral problems in PD. © 2007 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>dopamine</term></item><item><term>side‐effects</term></item><item><term>compulsion</term></item><item><term>impulsivity</term></item><item><term>age of onset.</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Research Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-01-16">Received</change><change when="2007-07-14">Registration</change><change when="2007-12-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/F512F630D798CBFDF1E35E72879BD0EC392B2AF8/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. 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F.</givenNames><familyName>Aitken</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2 #af3"><personName><givenNames>Barbara J.</givenNames><familyName>Sahakian</familyName><degrees>PhD, DClinPsych, FMedSci</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="GB" type="organization"><unparsedAffiliation>Department of Experimental Psychology, University of Cambridge, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="GB" type="organization"><unparsedAffiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="GB" type="organization"><unparsedAffiliation>Department of Psychiatry, University of Cambridge School of Medicine, Cambridge, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="GB" type="organization"><unparsedAffiliation>Cambridge Centre for Brain Repair, Department of Clinical Neuroscience, Addenbrooke's Hospital, Cambridge, United Kingdom</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="IT" type="organization"><unparsedAffiliation>Department of Neurology, San Raffaele Hospital, Milan, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">dopamine</keyword><keyword xml:id="kwd2">side‐effects</keyword><keyword xml:id="kwd3">compulsion</keyword><keyword xml:id="kwd4">impulsivity</keyword><keyword xml:id="kwd5">age of onset.</keyword></keywordGroup><fundingInfo><fundingAgency>Wellcome Trust</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Medical Research Council (MRC)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Parkinson's Disease Society (UK)</fundingAgency></fundingInfo><supportingInformation><p> This article contains supplementary material available via the Internet at <url href="http://www.interscience.wiley.com/jpages/0885-3185/suppmat"> http://www.interscience.wiley.com/jpages/0885‐3185/suppmat </url> . </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds21702:Punding_questionnaire"></mediaResource><caption>Questionnaire</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds21702:Example_Questionnaire_and_Scoring_Guide"></mediaResource><caption>Scoring Guide</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self‐report questionnaire was adapted to assess punding in the context of dysfunctional hobby‐related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non‐PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease‐related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT‐related nonmotor behavioral problems in PD. © 2007 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Predictors of punding in Parkinson's disease: Results from a questionnaire survey</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Predictors of Punding in Parkinson′s Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Predictors of punding in Parkinson's disease: Results from a questionnaire survey</title></titleInfo><name type="personal"><namePart type="given">Andrew J.</namePart><namePart type="family">Lawrence</namePart><namePart type="termsOfAddress">BA</namePart><affiliation>Department of Experimental Psychology, University of Cambridge, United Kingdom</affiliation><affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</affiliation><description>Correspondence: Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, United Kingdom</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Andrew D.</namePart><namePart type="family">Blackwell</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Psychiatry, University of Cambridge School of Medicine, Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Roger A.</namePart><namePart type="family">Barker</namePart><namePart type="termsOfAddress">MRCP, PhD</namePart><affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</affiliation><affiliation>Cambridge Centre for Brain Repair, Department of Clinical Neuroscience, Addenbrooke's Hospital, Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Spagnolo</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, San Raffaele Hospital, Milan, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luke</namePart><namePart type="family">Clark</namePart><namePart type="termsOfAddress">DPhil</namePart><affiliation>Department of Experimental Psychology, University of Cambridge, United Kingdom</affiliation><affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael R. F.</namePart><namePart type="family">Aitken</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Experimental Psychology, University of Cambridge, United Kingdom</affiliation><affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Barbara J.</namePart><namePart type="family">Sahakian</namePart><namePart type="termsOfAddress">PhD, DClinPsych, FMedSci</namePart><affiliation>Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom</affiliation><affiliation>Department of Psychiatry, University of Cambridge School of Medicine, Cambridge, United Kingdom</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2007-12-15</dateIssued><dateCaptured encoding="w3cdtf">2007-01-16</dateCaptured><dateValid encoding="w3cdtf">2007-07-14</dateValid><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">37</extent><extent unit="words">4904</extent></physicalDescription><abstract lang="en">Dopamine replacement therapy (DRT) for Parkinson's disease (PD) has recently been linked to the development of a number of nonmotor behavioral control problems. Punding, one of these nonmotor problems, is a term used to describe complex, purposeless stereotyped behaviors such as the repetitive handling or sorting of objects. A self‐report questionnaire was adapted to assess punding in the context of dysfunctional hobby‐related activities. We report the results of a survey of PD outpatients from a PD research clinic (n = 141) and non‐PD controls (n = 103); conducted to identify clinical and psychological factors predictive of punding behaviors. The PD group reported hobbies and activities, which scored significantly higher on the Punding Scale than controls. Higher impulsivity, poorer disease‐related quality of life, younger age of disease onset, and concomitant daily medication dosage from dopamine receptor agonists were independently predictive of higher Punding Scale scores in the PD group. These findings are similar to those seen in dopamine dysregulation syndrome, and provide further evidence for the role of impulsivity and age at disease onset in DRT‐related nonmotor behavioral problems in PD. © 2007 Movement Disorder Society</abstract><note type="funding">Wellcome Trust</note><note type="funding">Medical Research Council (MRC)</note><note type="funding">Parkinson's Disease Society (UK)</note><subject lang="en"><genre>Keywords</genre><topic>dopamine</topic><topic>side‐effects</topic><topic>compulsion</topic><topic>impulsivity</topic><topic>age of onset.</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> This article contains supplementary material available via the Internet at http://www.interscience.wiley.com/jpages/0885‐3185/suppmat .Supporting Info Item: Questionnaire - Scoring Guide - </note><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>22</number></detail><detail type="issue"><caption>no.</caption><number>16</number></detail><extent unit="pages"><start>2339</start><end>2345</end><total>7</total></extent></part></relatedItem><identifier type="istex">F512F630D798CBFDF1E35E72879BD0EC392B2AF8</identifier><identifier type="DOI">10.1002/mds.21702</identifier><identifier type="ArticleID">MDS21702</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2007 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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